According to hospital sources, condition of several people injured in the explosion is critical.
The explosion, which police attributed to a suicide bomber, took place at the entrance to the dargah at a time when scores of people had gathered to pay their respects.
He added that one police constable was killed while attempting to stop the suicide bomber from entering the shrine, while two other policemen were injured in the blast.
The attack follows a deadly bomb blast at the same shrine in the oil and gas rich Balochistan province in 2005, which killed 35 people.
No group has claimed responsibility for the bombing.
Later, addressing reporters, Balochistan home minister Mir Sarfaraz Bugti said that so far it appeared to be a suicide attack.
Four Crystal Palace Players Ruled Out With Injuries
Spanish worldwide David De Gea has been impressive so far this season and will likely keep his place in goal barring any injury. Conor Wickham and Wilfried Zaha will also miss out for Hodgson's side due to respective injuries.
The local administration has declared an emergency at hospitals in Sibbi and Dera Murad Jamali.
In February, a suicide bomber had killed more than 80 people and injured 250 others in an attack on the shrine of Lal Shahbaz Qalandar in Sehwan Sharif in Sindh.
Deputy Commissioner Asadullah Kakar confirmed that it was a suicide attack.
Pakistani security forces cordoned off the area and TV footage showed ambulances arriving at the scene of the blast.
Incidents involving attacks on religious places are not unique in Pakistan as the militant groups often carry out such attacks, specifically when a ritual is process in such sites. In a statement, he said that "terrorists have no religion" and that his government would act against militants with full might. The village is about 400km east of Quetta, the capital of Baluchistan province.
In November past year, at least 52 people were killed in a bombing at a shrine in the Hub district south of Jhal Magsi.
- Yankees win again, but AL East title hopes in trouble
- Storm romp over Cowboys in NRL GF
- London ban will not affect Uber service in Welwyn Hatfield
- Killer Clown Arrested in 27-year-old Florida cold case
- Trump Hails Saudi 'Positive Step' Allowing Women To Drive
- Palestine becomes Interpol member state
- PLISKOVA, MUGURUZA the latest to fall
- Bayern Munich's Carlo Ancelotti sacked after team's deteriorating form
- Accountancy giant Deloitte hit by cyber attack
- European Union executive calls for Spanish-Catalan talks after referendum violence